American Scientists Proved Impossible To Prevent Depression By Taking Vitamin D3
Researchers from the United States have found that long-term intake of vitamin D3 can not prevent depression, according to the publication of the journal of the American Medical Association (JAMA Network Open).
During the experiment, which lasted more than five years and involved 18,353 men and women over 50, half of them received vitamin D3 and omega-3, and half received a placebo. At the same time, 16.7 thousand patients had no history of depression, and 1679 people had a risk of relapse, but they were not treated for depression for two years before the start of the study.
It's worth mentioning that low blood levels of the active metabolite of vitamin D3-25-hydroxycholecalciferol-have usually been associated with a higher risk of depression in older people. But no long-term large-scale studies have been conducted on this issue.
"There were no significant differences between treatment groups concerning changes in mood indicators over time," the publication said.
Moreover, the risk of depression did not differ in the groups: 609 depressions or significant symptoms of depression were noted in the "vitamin D group" and 625 - in the "placebo group."
"Among adults aged 50 years and older without clinically significant depressive symptoms at baseline, treatment with vitamin D3 compared to placebo did not result in a statistically significant difference in the frequency and recurrence of depression or clinically significant depressive symptoms, or a change in mood scores over an average follow-up period of more than five years. These data do not support the use of vitamin D3 in adults to prevent depression," the scientists concluded.